Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20260924 | 0.90 | MAPK8 (0.35) | GAAMEN1ALDH1A1KMT2AMAPK8 | |
| SCHEMBL20260918 | 0.87 | CSNK2A2 (0.36) | MAPK8MAPK10 | |
| SCHEMBL21141159 | 0.82 | MAPK10 (0.39) | GAAMEN1ALDH1A1KMT2AMAPK8 | |
| SCHEMBL20242751 | 0.80 | RAPGEF4 (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL20260930 | 0.78 | BTK (0.31) | MAPK8MAPK10MAPK9 | |
| SCHEMBL18278851 | 0.77 | MAPK8 (0.34) | MAPK8MAPK10MAPK9 | |
| SCHEMBL20260875 | 0.76 | TNIK (0.54) | MAPK8MAPK10MAPK9EGFRJUN | |
| SCHEMBL18278293 | 0.76 | MAPK10 (0.48) | MAPK8MAPK10MAPK9POLBSTAT6 | |
| SCHEMBL20260545 | 0.76 | TNIK (0.43) | MAPK8MAPK10MAPK9STAT6JUN | |
| SCHEMBL20260395 | 0.75 | P2RX7 (0.39) | MAPK8MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |