Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18278231 | 0.88 | LRRK2 (0.35) | CSNK2A2CSNK2A1BTKATRLRRK2 | |
| SCHEMBL20260920 | 0.87 | GAA (0.41) | MAPK8MAPK10 | |
| SCHEMBL20260924 | 0.86 | MAPK8 (0.35) | MAPK8MAPK10 | |
| SCHEMBL18278381 | 0.84 | LRRK2 (0.35) | CSNK2A2CSNK2A1ATRLRRK2KCNH2 | |
| SCHEMBL20260546 | 0.84 | P2RX7 (0.37) | ATRJAK2PTK2TBK1SYK | |
| SCHEMBL18277832 | 0.83 | ATR (0.35) | CSNK2A2CSNK2A1BTKATRLRRK2 | |
| SCHEMBL20260877 | 0.83 | TBK1 (0.43) | JAK2PTK2TBK1MAPK8MAPK10 | |
| SCHEMBL20260500 | 0.83 | TBK1 (0.34) | CSNK2A2CSNK2A1ATRLRRK2KCNH2 | |
| SCHEMBL20260507 | 0.83 | TBK1 (0.38) | JAK2PTK2TBK1MAPK8MAPK10 | |
| SCHEMBL18278671 | 0.81 | ATR (0.35) | CSNK2A2CSNK2A1ATRLRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |