SCHEMBL20266456

SCHEMBL20266456

Cn1cncc1Cn1c(CO)nc2ccc(C(=O)O)cc21

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 12/20 0.51
▸ AGTR1 P30556 4/20 0.42
▸ AGTR2 P50052 4/20 0.42
▸ ACSS2 Q9NR19 1/20 0.41
▸ LGALS8 O00214 1/20 0.41
▸ PPARG P37231 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20266333 0.88 GLP1R (0.44) GLP1RACSS2
SCHEMBL31159736 0.79 GLP1R (0.45) GLP1RACSS2
SCHEMBL20266537 0.79 GLP1R (0.45) GLP1RACSS2
Hydrochloric Acid SCHEMBL28910361 0.78 GLP1R (0.44) GLP1RACSS2
Hydrochloric Acid SCHEMBL30269640 0.78 GLP1R (0.44) GLP1RACSS2
SCHEMBL28860552 0.77 AGTR1 (0.50) AGTR1AGTR2ACSS2PPARG
SCHEMBL30740795 0.76 ACSS2 (0.46) GLP1RACSS2PPARG
SCHEMBL29826815 0.76 ACSS2 (0.46) GLP1RACSS2PPARG
SCHEMBL29281094 0.75 LGALS8 (0.55) LGALS8PPARG
SCHEMBL24792073 0.74 GLP1R (0.60) GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257052-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2025-08-14 — — US disclosed
US-12319669-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2025-06-03 — — US disclosed
US-20240034725-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2024-02-01 — — US disclosed
US-11802121-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2023-10-31 — — US disclosed
US-20230124938-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2023-04-20 — — US disclosed
EP-3555064-B9 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER (US) 2023-03-01 — — EP disclosed
US-11512070-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2022-11-29 — — US disclosed
EP-3555064-B1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER (US) 2022-11-23 — — EP disclosed
US-20210047298-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2021-02-18 — — US disclosed
US-10851081-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2020-12-01 — — US disclosed
US-20200255406-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2020-08-13 — — US disclosed
US-10669259-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2020-06-02 — — US disclosed
EP-3555064-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF Pfizer Inc. (US) 2019-10-23 — — EP disclosed
US-20190119255-A1 GLP-1 Receptor Agonists and Uses Thereof PFIZER INC. (US) 2019-04-25 — — US disclosed
US-10208019-B2 GLP-1 receptor agonists and uses thereof PFIZER INC. (US) 2019-02-19 — — US disclosed
US-20180170908-A1 GLP-1 Agonists and Uses Thereof PFIZER INC. (US) 2018-06-21 — — US disclosed
WO-2018109607-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF PFIZER INC. (US) 2018-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10669259-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-11512070-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20250257052-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20180170908-A1 GLP-1 Agonists and Uses Thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 992/4885AGTR2 1332/4885
US-10851081-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-12319669-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20190119255-A1 GLP-1 Receptor Agonists and Uses Thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-11802121-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-10208019-B2 GLP-1 receptor agonists and uses thereof GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20210047298-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20240034725-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20200255406-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885
US-20230124938-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 GLP1R 1/4885AGTR1 607/4885AGTR2 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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