Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | JUN | P05412 | 7/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.36 |
| ▸ | RELA | Q04206 | 7/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 3/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18358420 | 0.83 | MAP3K5 (0.39) | MAP3K5JAK2TP53GPR35JUN | |
| SCHEMBL2785921 | 0.78 | MAP3K5 (0.70) | MAP3K5TP53LMNANPC1HPGD | |
| SCHEMBL20280010 | 0.75 | GRIN1 (0.38) | TP53GRIN1GRIN2ANPC1RAB9A | |
| SCHEMBL2789371 | 0.72 | KDM4E (0.40) | JAK2THRBGRIN1GRIN2AKDM4E | |
| SCHEMBL20839870 | 0.70 | JAK1 (0.37) | MAP3K5JAK2TP53KDM4ELMNA | |
| SCHEMBL17252255 | 0.66 | TTR (0.41) | GPR35THRBGRIN1GRIN2AKDM4E | |
| SCHEMBL20839881 | 0.63 | TDP2 (0.56) | JAK2LMNAJAK1 | |
| SCHEMBL18358241 | 0.62 | KDM4E (0.36) | GRIN1GRIN2AKDM4EHPGD | |
| SCHEMBL27682864 | 0.62 | SLC13A3 (0.60) | GPR35JUNNFKB1NFKB2RELA | |
| SCHEMBL5833345 | 0.62 | GPR35 (0.66) | GPR35JUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE3A, PDE4D | MAP3K5 495/4885JAK2 1451/4885TP53 4220/4885 |
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | PDE2A, PDE3A, PDE4D | MAP3K5 495/4885JAK2 1451/4885TP53 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.