Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839881 | 0.72 | TDP2 (0.56) | JAK1JAK2TDP2LMNAPIK3CG | |
| SCHEMBL20266798 | 0.70 | MAP3K5 (0.42) | JAK1JAK2NPY5RLMNAKDM4E | |
| SCHEMBL20844717 | 0.69 | NUDT1 (0.38) | PIK3CGKDM4EALDH1A1NPC1RAB9A | |
| Cyclopropane SCHEMBL16986940 | 0.66 | JAK2 (0.72) | JAK1JAK2 | |
| SCHEMBL25310876 | 0.64 | JAK1 (0.48) | JAK1JAK2MAP3K5 | |
| SCHEMBL18340747 | 0.62 | S1PR2 (0.48) | LMNAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| Cyclopropane SCHEMBL16986950 | 0.60 | JAK1 (0.70) | JAK1JAK2MAP3K5 | |
| SCHEMBL20472534 | 0.60 | AHR (0.48) | JAK2TDP2PIK3CGMAPTPIK3CD | |
| SCHEMBL16965029 | 0.58 | S1PR2 (0.44) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2473325 | 0.58 | MAPT (0.37) | LMNAKDM4EALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057946-A1 | MULTI-CYCLIC AROMATIC COMPOUNDS AS FACTOR D INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-28 | — | — | WO | disclosed |