Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274205 | 0.86 | SOS1 (0.51) | KCNH2CACNA1GTP53FASNLMNA | |
| SCHEMBL20274177 | 0.85 | AKR1B1 (0.48) | KCNH2CACNA1GTP53MEN1KMT2A | |
| SCHEMBL20274152 | 0.79 | HTR2B (0.43) | CYP2D6CYP2C9ALOX15TSHRCYP2C19 | |
| SCHEMBL20274207 | 0.74 | HDAC6 (0.49) | KCNH2TP53CYP2D6CYP2C9ALOX15 | |
| SCHEMBL20274136 | 0.74 | MEN1 (0.42) | CYP2D6CYP2C9ALOX15TSHRCYP2C19 | |
| SCHEMBL23336086 | 0.73 | FAAH (0.57) | MCHR1CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL24338807 | 0.72 | PIK3CD (0.43) | PIK3CDPIK3CBCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29491254 | 0.72 | PIK3CD (0.43) | PIK3CDPIK3CBCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL20274151 | 0.71 | FAAH (0.48) | TP53CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL23932546 | 0.71 | KDM4E (0.45) | KCNH2CACNA1GPIK3CDPIK3CBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3428162-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-2922845-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | MERIAL INC (US) | 2018-06-20 | — | — | EP | disclosed |