Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274131 | 0.86 | HRH4 (0.48) | ALDH1A1HRH3CYP2C9TSHRCACNA2D1 | |
| SCHEMBL20274215 | 0.85 | PIM1 (0.43) | POLBHRH3CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL20274187 | 0.80 | ALDH1A1 (0.45) | POLBALDH1A1SIGMAR1HRH3CYP2D6 | |
| SCHEMBL15750162 | 0.78 | F2 (0.57) | ALDH1A1F2TPSAB1TPSD1TPSG1 | |
| SCHEMBL20274152 | 0.76 | HTR2B (0.43) | HRH3CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL15750158 | 0.70 | PIM1 (0.41) | POLBHRH3CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL20274167 | 0.68 | HRH3 (0.38) | POLBHRH3CYP2D6CYP2C9ALOX15 | |
| SCHEMBL20274161 | 0.67 | KCNH2 (0.52) | CYP2D6CYP2C9ALOX15TSHRCYP2C19 | |
| SCHEMBL4792814 | 0.67 | NPC1 (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL20274116 | 0.67 | POLB (0.54) | POLBALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3428162-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-2922845-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | MERIAL INC (US) | 2018-06-20 | — | — | EP | disclosed |