Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPX4 | P36969 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274172 | 0.86 | POLB (0.38) | KDM4ETSHRHRH3ALDH1A1CACNA2D1 | |
| SCHEMBL20274215 | 0.83 | PIM1 (0.43) | HRH3CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL20274196 | 0.78 | HRH4 (0.73) | HRH4NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL20274139 | 0.76 | HRH4 (0.47) | HRH4NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL20274200 | 0.69 | HRH3 (0.40) | HRH3CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL15750158 | 0.68 | PIM1 (0.41) | HRH3CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL20274205 | 0.67 | SOS1 (0.51) | AKR1C3MEN1KMT2ACACNA1GLMNA | |
| SCHEMBL12248487 | 0.67 | ALOX5 (0.56) | HRH4ALOX5NPC1RAB9AKDM4E | |
| SCHEMBL20274173 | 0.67 | AKR1C3 (0.68) | KDM4EAKR1C3TSHRMEN1KMT2A | |
| SCHEMBL20274216 | 0.67 | HTR2B (0.46) | KDM4EAKR1C3TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3428162-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-2922845-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | MERIAL INC (US) | 2018-06-20 | — | — | EP | disclosed |