Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CLPP | Q16740 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337786 | 0.90 | MAOB (0.36) | WDR5P2RX7EZH2AKR1B1MAOB | |
| SCHEMBL2028235 | 0.88 | AKR1B1 (0.35) | WDR5HTR2AGRM2AKR1B1CLPP | |
| SCHEMBL1336152 | 0.85 | OPRK1 (0.36) | WDR5P2RX7HTR2AGRM2EZH2 | |
| SCHEMBL1335863 | 0.83 | MAOB (0.36) | WDR5P2RX7AKR1B1KMT2AMAOB | |
| SCHEMBL1338248 | 0.83 | SIGMAR1 (0.33) | P2RX7HTR2AGRM2DRD4 | |
| SCHEMBL14007686 | 0.82 | HTR2A (0.32) | WDR5P2RX7HTR2AGRM2EZH2 | |
| SCHEMBL1338165 | 0.81 | P2RX7 (0.35) | P2RX7EZH2DRD2DRD4MAOB | |
| SCHEMBL1337557 | 0.81 | P2RX7 (0.34) | WDR5P2RX7AKR1B1MAOBADORA2A | |
| SCHEMBL2027046 | 0.81 | AKR1B1 (0.43) | WDR5P2RX7AKR1B1KMT2AMAOB | |
| SCHEMBL4793599 | 0.80 | PREP (0.34) | WDR5P2RX7AKR1B1MAOBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968564-B2 | HIV integrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100204201-A1 | HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204201-A1 | HIV INTEGRASE INHIBITORS | REV1, CDKN1A, CCNI | WDR5 1763/4885P2RX7 4051/4885HTR2A 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.