Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507581 | 0.85 | TLR9 (0.38) | HTR1DTSHRKDM4ELMNACYP3A4 | |
| SCHEMBL13533992 | 0.83 | KDM4E (0.50) | TSHRKDM4ELMNACYP3A4SREBF2 | |
| SCHEMBL6638892 | 0.81 | KDM4E (0.38) | HTR1DTSHRKDM4ELMNACYP3A4 | |
| SCHEMBL12394763 | 0.81 | HRH4 (0.40) | TSHRKDM4ELMNACYP3A4HRH4 | |
| SCHEMBL18799858 | 0.80 | LMNA (0.40) | TSHRKDM4ELMNACYP3A4SREBF2 | |
| SCHEMBL29348302 | 0.79 | RXRA (0.38) | TSHRKDM4ELMNACYP3A4CYP2C9 | |
| SCHEMBL2547950 | 0.79 | KCNH2 (0.42) | TSHRKDM4ELMNACYP3A4SREBF2 | |
| SCHEMBL11994370 | 0.79 | CYP1A2 (0.46) | TSHRKDM4ELMNACYP3A4SREBF2 | |
| SCHEMBL23015678 | 0.78 | KDM4E (0.40) | TSHRKDM4ELMNACYP3A4CHRNA7 | |
| SCHEMBL19821720 | 0.77 | KDM4E (0.35) | TSHRKDM4ELMNACYP3A4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018107200-A1 | HEPARANASE INHIBITORS AND USE THEREOF | Beta Therapeutics Pty Ltd (AU) | 2018-06-21 | — | — | WO | disclosed |