Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533992 | 0.83 | KDM4E (0.50) | RXRAGRIN1GRIN2BKDM4ELMNA | |
| SCHEMBL6638892 | 0.81 | KDM4E (0.38) | RXRAGRIN1GRIN2BKDM4ELMNA | |
| SCHEMBL20280911 | 0.81 | HRH1 (0.46) | HRH4SYKRXRAGRIN1GRIN2B | |
| SCHEMBL12120617 | 0.81 | RXRA (0.35) | NOS3NOS1NOS2RXRAGRIN1 | |
| SCHEMBL18799858 | 0.80 | LMNA (0.40) | NOS3NOS1NOS2RXRAGRIN1 | |
| SCHEMBL13995011 | 0.79 | NOS1 (0.51) | HRH4SYKNOS3NOS1NOS2 | |
| SCHEMBL24868449 | 0.79 | ALDH1A1 (0.34) | RXRAGRIN1GRIN2BAAK1KDM4E | |
| SCHEMBL2547950 | 0.79 | KCNH2 (0.42) | TDP1KDM4ELMNACYP3A4TSHR | |
| SCHEMBL29348302 | 0.79 | RXRA (0.38) | NOS1NOS2RXRAGRIN1GRIN2B | |
| SCHEMBL11994370 | 0.79 | CYP1A2 (0.46) | NOS3NOS1NOS2RXRAGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174271-B2 | 6-membered uracil isosteres | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2021-11-16 | — | — | US | disclosed |
| US-20190270756-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2019-09-05 | — | — | US | disclosed |
| US-10308653-B2 | Diazepane derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-9637477-B2 | Therapeutic substituted pyrroles | ALLERGAN, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-20150336940-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | ALLERGAN, INC. | 2015-11-26 | — | — | US | disclosed |
| US-7985765-B2 | Therapeutic substituted pyrroles | ALLERGAN, INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-20100048664-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | ALLERGAN, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174271-B2 | 6-membered uracil isosteres | UNG, DUT, DPYD | HRH4 4514/4885SYK 4158/4885NOS3 3449/4885 |
| US-10308653-B2 | Diazepane derivatives and uses thereof | BRDT, BRD4, BAZ2A | HRH4 2335/4885SYK 4597/4885NOS3 3270/4885 |
| US-20150336940-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | PTGS2, PTGES2, PTGIS | HRH4 2242/4885SYK 3656/4885NOS3 130/4885 |
| US-20190270756-A1 | 6-MEMBERED URACIL ISOSTERES | UNG, DUT, DPYD | HRH4 4514/4885SYK 4158/4885NOS3 3449/4885 |
| US-20100048664-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | GOT2, FARS2, THPO | HRH4 2516/4885SYK 858/4885NOS3 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.