Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031451 | 0.99 | HDAC1 (0.67) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL2033239 | 0.95 | MCL1 (0.67) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL2027869 | 0.90 | MCL1 (0.70) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL12641424 | 0.85 | HDAC1 (0.61) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL12580587 | 0.84 | HDAC1 (0.60) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL12641398 | 0.80 | HDAC1 (0.58) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL6325635 | 0.79 | MCL1 (1.00) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL4440934 | 0.77 | HDAC1 (0.62) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL4440742 | 0.76 | MCL1 (0.63) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 | |
| SCHEMBL19287090 | 0.75 | MCL1 (0.62) | HDAC1HDAC2HDAC8MCL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136823-A1 | COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF | INSTITUT PASTEUR DE LILLE (FR) | 2011-06-09 | — | — | US | claimed |
| US-8338599-B2 | Compounds having a potentiating effect on the activity of ethionamide and uses thereof | INSTITUT PASTEUR DE LILLE (FR) | 2012-12-25 | — | — | US | disclosed |
| US-20110136823-A1 | COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF | INSTITUT PASTEUR DE LILLE (FR) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136823-A1 | COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF | EPX, PGLS, ENPEP | HDAC1 139/4885HDAC2 463/4885HDAC8 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.