Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998093 | 0.77 | POLB (0.44) | POLBALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL2998092 | 0.77 | POLB (0.44) | POLBALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL1779238 | 0.77 | POLB (0.52) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL8674209 | 0.70 | POLB (0.57) | POLBALDH1A1LMNAGAAMAPT | |
| (Z)-1,2-Diphenylethene SCHEMBL27619643 | 0.67 | MAOB (0.65) | CYP11B1CYP11B2KMT2AALDH1A1LMNA | |
| (Z)-1,2-Diphenylethene SCHEMBL3477795 | 0.67 | MAOB (0.65) | CYP11B1CYP11B2KMT2AALDH1A1LMNA | |
| SCHEMBL8525606 | 0.67 | CYP11B1 (0.45) | CYP11B1CYP11B2KMT2AALDH1A1HPGD | |
| (Z)-1,2-Diphenylethene SCHEMBL9134296 | 0.67 | MAOB (0.73) | CYP11B1CYP11B2KMT2AALDH1A1LMNA | |
| (Z)-1,2-Diphenylethene SCHEMBL443 | 0.67 | MAOB (0.73) | CYP11B1CYP11B2KMT2AALDH1A1LMNA | |
| (Z)-1,2-Diphenylethene SCHEMBL22712863 | 0.67 | MAOB (0.73) | CYP11B1CYP11B2KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-03-23 | — | — | US | disclosed |
| EP-3555065-B1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2021-02-24 | — | — | EP | disclosed |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-03-05 | — | — | US | disclosed |
| WO-2018111803-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | RORB, RORC, RORA | POLB 4032/4885CYP11B1 27/4885CYP11B2 31/4885 |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORC, RORB, RORA | POLB 4044/4885CYP11B1 29/4885CYP11B2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.