Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2165060 | 1.00 | GABRA1 (0.51) | GABRA1SIGMAR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2028471 | 1.00 | GABRA1 (0.51) | GABRA1SIGMAR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2164403 | 0.84 | KDM4E (0.46) | GABRA1SIGMAR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL737915 | 0.84 | KDM4E (0.46) | GABRA1SIGMAR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1937074 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM | |
| SCHEMBL2166114 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM | |
| SCHEMBL1937076 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM | |
| SCHEMBL2472098 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM | |
| SCHEMBL2474936 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM | |
| SCHEMBL2472101 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ACHEPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598367-B2 | Nitrogen-containing heterocyclic compound and pest control agent | NIPPON SODA CO., LTD. (JP) | 2013-12-03 | — | — | US | disclosed |
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| US-20130137876-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2013-05-30 | — | — | US | disclosed |
| US-8362257-B2 | Nitrogen-containing heterocyclic compound and pest control agent | NIPPON SODA CO., LTD. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |
| US-7985762-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |
| US-20110166358-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2332927-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | Nippon Soda Co., Ltd. (JP) | 2011-06-15 | — | — | EP | disclosed |
| CN-101316852-A | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2008-12-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137876-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | CBR3, CBR1, NOXO1 | GABRA1 4444/4885SIGMAR1 380/4885ALDH1A1 4081/4885 |
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | GABRA1 4356/4885SIGMAR1 3320/4885ALDH1A1 1374/4885 |
| US-20110166358-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | CBR3, CBR1, NOXO1 | GABRA1 4444/4885SIGMAR1 380/4885ALDH1A1 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.