Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65533 | 0.87 | THRB (0.59) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL679847 | 0.85 | THRB (0.57) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL9717112 | 0.83 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL19588493 | 0.83 | THRB (0.51) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL9559753 | 0.81 | THRB (0.53) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL9560047 | 0.81 | THRB (0.53) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL379171 | 0.81 | THRB (0.53) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL13129202 | 0.81 | THRB (0.58) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL9717150 | 0.81 | THRB (0.46) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL9717130 | 0.81 | THRB (0.46) | THRBTSHRALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861850-A | CONTACT LENSES | PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) | 1989-08-29 | — | — | US | claimed |
| US-4861840-A | Novel siloxanyl acrylic monomer and gas-permeable contact lenses made therefrom | BARNES-HIND, INC. (US) | 1989-08-29 | — | — | US | claimed |
| JP-63253091-A | — | — | None | — | — | JP | disclosed |
| EP-4097155-B1 | ACTINICALLY-CROSSLINKABLE POLYSILOXANE-POLYGLYCEROL BLOCK COPOLYMERS AND METHODS OF MAKING AND USE THEREOF | CLEARLAB SG PTE LTD (SG) | 2025-08-20 | — | — | EP | disclosed |
| US-12037463-B2 | Antimicrobial ophthalmic devices comprising polysiloxane-polyglycerol block copolymers and methods of making and use thereof | Clearlab Sg Pte Ltd. (SG) | 2024-07-16 | — | — | US | disclosed |
| US-12024597-B2 | Wound dressings comprising polysiloxane-polyglycerol block copolymers and methods of making and use thereof | Clearlab Sg Pte Ltd. (SG) | 2024-07-02 | — | — | US | disclosed |
| US-20230227613-A1 | ANTIMICROBIAL OPHTHALMIC DEVICES COMPRISING POLYSILOXANE-POLYGLYCEROL BLOCK COPOLYMERS AND METHODS OF MAKING AND USE THEREOF | CLEARLAB SG PTE LTD (SG) | 2023-07-20 | — | — | US | disclosed |
| US-20230212357-A1 | WOUND DRESSINGS COMPRISING POLYSILOXANE-POLYGLYCEROL BLOCK COPOLYMERS AND METHODS OF MAKING AND USE THEREOF | CLEARLAB SG PTE LTD (SG) | 2023-07-06 | — | — | US | disclosed |
| US-11649325-B2 | Actinically-crosslinkable polysiloxane-polyglycerol block copolymers and methods of making and use thereof | Clearlab Sg Pte Ltd. (SG) | 2023-05-16 | — | — | US | disclosed |
| EP-4097155-A1 | ACTINICALLY-CROSSLINKABLE POLYSILOXANE-POLYGLYCEROL BLOCK COPOLYMERS AND METHODS OF MAKING AND USE THEREOF | Clearlab SG Pte Ltd (SG) | 2022-12-07 | — | — | EP | disclosed |
| US-20210246270-A1 | ACTINICALLY-CROSSLINKABLE POLYSILOXANE-POLYGLYCEROL BLOCK COPOLYMERS AND METHODS OF MAKING AND USE THEREOF | Clearlab Sg Pte Ltd. (SG) | 2021-08-12 | — | — | US | disclosed |
| US-20080274304-A1 | Functionalized Photoreactive Compounds | ROLIC AG (CH) | 2008-11-06 | — | — | US | disclosed |
| EP-1764405-A1 | Functionalized photoreactive compounds | Rolic AG (CH) | 2007-03-21 | — | — | EP | disclosed |
| US-5093447-A | Contact lenses | NOVICKY NICK N (CA) | 1992-03-03 | — | — | US | disclosed |
| US-4963159-A | ADHERING POLYMERIC COLOR COAT TO LENS, ISOCYANATE CROSSLINKERS | SCHERING CORPORATION (US) | 1990-10-16 | — | — | US | disclosed |
| US-4948855-A | COPOLYMER OF UNSATURATED SILOXANYLALKOXYESTER AND VINYL SILFONE | PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) | 1990-08-14 | — | — | US | disclosed |
| US-4861850-A | CONTACT LENSES | PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) | 1989-08-29 | — | — | US | disclosed |
| US-4861840-A | Novel siloxanyl acrylic monomer and gas-permeable contact lenses made therefrom | BARNES-HIND, INC. (US) | 1989-08-29 | — | — | US | disclosed |
| JP-S63253091-A | ((METH)ACRYLOXYALKOXY)SILANE HAVING TRIMETHYLSILOXY GROUP | TOSHIBA SILICONE CO LTD | 1988-10-20 | — | — | JP | disclosed |
| US-4743106-A | POLYMER HAVING AN ORGANOSILOXANYLALKOXY ESTER OF (METH)ACRYLIC ACID MONOMER; MACHINING | Devou, Maureen J. (CA) | 1988-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274304-A1 | Functionalized Photoreactive Compounds | PCNA, PIN1, MAP1LC3C | THRB 4831/4885TSHR 4847/4885ALDH1A1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.