Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30350671 | 0.68 | MTNR1A (0.55) | NOTUMTSHRALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL19510713 | 0.68 | MTNR1A (0.55) | NOTUMTSHRALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL253656 | 0.67 | LMNA (0.43) | HTTNOTUMTSHRNPSR1MAPK1 | |
| SCHEMBL2591774 | 0.67 | MEN1 (0.41) | TSHRALDH1A1KDM4EKMT2AHSD17B10 | |
| SCHEMBL10372330 | 0.67 | ALDH1A1 (0.40) | TSHRALDH1A1LMNAKMT2AHSD17B10 | |
| SCHEMBL24739554 | 0.66 | GRIK1 (0.38) | ALDH1A1SMN1; SMN2CYP4F2CYP4A11MAPT | |
| SCHEMBL24739023 | 0.66 | GRIK1 (0.38) | ALDH1A1SMN1; SMN2CYP4F2CYP4A11MAPT | |
| SCHEMBL11160437 | 0.65 | ALDH1A1 (0.60) | TSHRNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL10474630 | 0.65 | MTNR1A (0.45) | NPSR1ALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL196131 | 0.65 | HPGD (0.61) | HTTNOTUMTSHRNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401269-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099039-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-02 | — | — | WO | disclosed |