Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901785 | 0.86 | MAPT (0.43) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL19063506 | 0.75 | KMT2A (0.46) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL14224951 | 0.74 | BCHE (0.46) | LMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL11661891 | 0.74 | ALDH1A1 (0.65) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL2338541 | 0.74 | MAPT (0.50) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL3477664 | 0.74 | MAPT (1.00) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL10513227 | 0.72 | MAOA (0.50) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL3477702 | 0.72 | MAPT (0.96) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL26012277 | 0.72 | MAOA (0.50) | MAPTPOLBLMNAGAAEPHX1 | |
| SCHEMBL16755954 | 0.72 | MAPT (0.96) | MAPTPOLBLMNAGAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |