Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291392 | 0.86 | MAPT (0.58) | MAPTLMNAPOLBGAAMEN1 | |
| SCHEMBL14790647 | 0.76 | ADRB1 (0.46) | MAPTLMNAPOLBGAAADRB1 | |
| SCHEMBL2708330 | 0.76 | MAPT (0.73) | MAPTLMNAPOLBGAAADRB1 | |
| SCHEMBL24762157 | 0.76 | FPR2 (0.36) | KHKCRBN | |
| Hydrochloric Acid SCHEMBL16514506 | 0.75 | MAPT (0.71) | MAPTLMNAPOLBGAAADRB1 | |
| Hydrochloric Acid SCHEMBL29847576 | 0.75 | MAPT (0.71) | MAPTLMNAPOLBGAAADRB1 | |
| Hydrochloric Acid SCHEMBL14782734 | 0.75 | ADRB1 (0.45) | MAPTLMNAPOLBGAAADRB1 | |
| SCHEMBL5608590 | 0.73 | BCHE (0.59) | MAPTLMNAPOLBGAAMEN1 | |
| SCHEMBL1879475 | 0.73 | MEN1 (0.53) | POLBCA1CA2MEN1KMT2A | |
| SCHEMBL24529786 | 0.72 | HTR2C (0.51) | CRBNPTGIRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |