Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.54 |
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287897 | 0.84 | LRRK2 (0.68) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL27717171 | 0.77 | MKNK1 (0.58) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL1672674 | 0.75 | IDO1 (0.78) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL1328336 | 0.70 | LRRK2 (1.00) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL30316298 | 0.70 | LRRK2 (1.00) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL855531 | 0.70 | ALDH1A1 (1.00) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL30768403 | 0.70 | ALDH1A1 (1.00) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL17313371 | 0.70 | HSD17B10 (0.51) | KDM4EGAAALDH1A1MAPK1CYP3A4 | |
| SCHEMBL28376527 | 0.70 | LRRK2 (0.68) | LRRK2IDO1KDM4EGAAALDH1A1 | |
| SCHEMBL30130217 | 0.70 | LRRK2 (0.68) | LRRK2IDO1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011116786-A | 3-(INDAZOL-5-YL)-(1, 2, 4) TRIAZINE DERIVATIVE AND RELATED COMPOUND AS PROTEIN KINASE INHIBITOR FOR TREATING CANCER | SCHERING CORP | 2011-06-16 | — | — | JP | disclosed |