Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20296817 | 0.84 | MEN1 (0.43) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4154983 | 0.80 | TRPM8 (0.41) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL20296577 | 0.78 | TRPM8 (0.38) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL20296595 | 0.77 | GRM2 (0.46) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL17559731 | 0.75 | MEN1 (0.44) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL31165745 | 0.74 | MEN1 (0.55) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL30170784 | 0.71 | PAX8 (0.43) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL20315161 | 0.71 | PAX8 (0.43) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL29517495 | 0.71 | PAX8 (0.43) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19616668 | 0.70 | KMT2A (0.46) | MEN1KMT2AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-A2 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | Amgen Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018119183-A2 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. (US) | 2018-06-28 | — | — | WO | disclosed |