Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20296817 | 0.81 | MEN1 (0.43) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20304513 | 0.80 | MEN1 (0.46) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20296577 | 0.75 | TRPM8 (0.38) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27677221 | 0.75 | CYP1A2 (0.41) | TRPM8MEN1KMT2ACYP1A2 | |
| SCHEMBL17456220 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL30170784 | 0.74 | PAX8 (0.43) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29517495 | 0.74 | PAX8 (0.43) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20315161 | 0.74 | PAX8 (0.43) | TRPM8KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL17456213 | 0.73 | NPC1 (0.41) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL17559731 | 0.73 | MEN1 (0.44) | TRPM8KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331911-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2020-10-22 | — | — | US | disclosed |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331911-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | TRPM8 3686/4885KDM4E 3689/4885ALDH1A1 3370/4885 |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | TRPM8 3884/4885KDM4E 1821/4885ALDH1A1 2874/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | TRPM8 3923/4885KDM4E 1568/4885ALDH1A1 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.