Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20315161 | 1.00 | PAX8 (0.43) | PAX8BRD4TRPM8NCEH1MEN1 | |
| SCHEMBL29517495 | 1.00 | PAX8 (0.43) | PAX8BRD4TRPM8NCEH1MEN1 | |
| SCHEMBL20296577 | 0.88 | TRPM8 (0.38) | PAX8BRD4TRPM8NCEH1MEN1 | |
| SCHEMBL20296817 | 0.80 | MEN1 (0.43) | TRPM8NCEH1MEN1KMT2AALDH1A1 | |
| SCHEMBL22029263 | 0.80 | CTSS (0.37) | PAX8TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL3633134 | 0.77 | PAX8 (0.43) | PAX8BRD4TRPM8NCEH1ALDH1A1 | |
| SCHEMBL31453184 | 0.75 | PAX8 (0.38) | PAX8BRD4 | |
| SCHEMBL68085 | 0.75 | PAX8 (0.42) | PAX8BRD4NCEH1MEN1KMT2A | |
| SCHEMBL4154983 | 0.74 | TRPM8 (0.41) | TRPM8MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL17559731 | 0.73 | MEN1 (0.44) | TRPM8MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626923-A | KRAS G12C inhibitors and methods of use thereof | 美国安进公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-110997668-B | KRAS G12C inhibitors and methods of use thereof | 美国安进公司 | 2022-11-01 | — | — | CN | disclosed |