Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CD63 | P08962 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20306321 | 0.88 | HSD11B1 (0.46) | HRH3PIK3CAMTORACVR1KDM4E | |
| SCHEMBL19965717 | 0.85 | PIK3CA (0.43) | RORCENPP2HRH3CD63SYK | |
| SCHEMBL10255059 | 0.80 | ENPP2 (0.45) | RORCENPP2CD63SYKPIK3CA | |
| SCHEMBL14930374 | 0.78 | SYK (0.40) | RORCENPP2CD63SYKPIK3CA | |
| SCHEMBL29695797 | 0.75 | CHRNB2 (0.54) | ENPP2CD63SYKESRRGACVR1 | |
| SCHEMBL19497344 | 0.75 | ENPP2 (0.38) | RORCENPP2CD63SYKPIK3CA | |
| SCHEMBL14341117 | 0.75 | CHRNB2 (0.54) | CDK4 | |
| SCHEMBL16427563 | 0.75 | CHRNB2 (0.54) | ENPP2CD63SYKESRRGACVR1 | |
| SCHEMBL14916901 | 0.75 | PIK3CA (0.50) | ENPP2CD63SYKPIK3CAMTOR | |
| SCHEMBL16437227 | 0.75 | DHFR (0.37) | RORCENPP2CD63SYKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | RORC 1051/4885ENPP2 407/4885HRH3 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.