Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTH | P32929 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | RRM2 | P31350 | 3/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23420036 | 0.79 | CTH (0.51) | CTHNOS3NOS1NOS2PLAU | |
| SCHEMBL19003421 | 0.79 | CTH (0.51) | CTHNOS3NOS1NOS2PLAU | |
| SCHEMBL31590419 | 0.78 | — | — | |
| SCHEMBL159686 | 0.78 | — | — | |
| SCHEMBL21645884 | 0.77 | CTH (0.54) | CTHNOS3NOS1NOS2PLAU | |
| SCHEMBL21645883 | 0.77 | CTH (0.54) | CTHNOS3NOS1NOS2PLAU | |
| Hydrochloric Acid SCHEMBL4624039 | 0.76 | NOS3 (0.45) | CTHNOS3NOS1NOS2PLAU | |
| Iodide SCHEMBL27462160 | 0.76 | CTH (0.53) | CTHNOS3NOS1NOS2PLAU | |
| SCHEMBL25742795 | 0.75 | CTH (0.49) | CTHNOS3NOS1NOS2PLAU | |
| SCHEMBL21393779 | 0.75 | KDM4E (0.36) | FGF23KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3339303-A1 | ARYL AND HETEROARYL FUSED LACTAMS | Pfizer Inc (US) | 2018-06-27 | — | — | EP | disclosed |