Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022816 | 0.82 | FGF23 (0.43) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL13714099 | 0.76 | LMNA (0.44) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL20310312 | 0.75 | CTH (0.48) | KDM4EALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7301605 | 0.66 | KDM4E (0.47) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL29496114 | 0.66 | P2RX7 (0.61) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL187727 | 0.66 | KDM4E (0.55) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL70978 | 0.66 | P2RX7 (0.61) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL6263675 | 0.66 | KDM4E (0.57) | KDM4EALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL21958003 | 0.66 | TDP1 (0.53) | KDM4EALDH1A1TDP1ALOX15TSHR | |
| SCHEMBL21896039 | 0.66 | LMNA (0.41) | KDM4EALDH1A1TDP1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |