Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 1/20 | 0.52 |
| ▸ | RNASEL | Q05823 | 9/20 | 0.50 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20327583 | 1.00 | STING1 (0.52) | STING1RNASELFUT5P2RY2P2RY4 | |
| SCHEMBL20324735 | 0.90 | RNASEL (0.62) | RNASELP2RY2 | |
| SCHEMBL20325275 | 0.89 | POLB (0.47) | STING1FUT5P2RY2P2RY4P2RY6 | |
| SCHEMBL20324866 | 0.84 | RNASEL (0.55) | RNASEL | |
| SCHEMBL20324732 | 0.83 | P2RY2 (0.52) | RNASELFUT5P2RY2P2RY4P2RY6 | |
| SCHEMBL22399211 | 0.83 | RNASEL (0.54) | STING1RNASELTGM2 | |
| SCHEMBL23061368 | 0.83 | TAS1R3 (0.54) | RNASELP2RY2 | |
| SCHEMBL22352118 | 0.83 | TAS1R3 (0.54) | RNASELP2RY2 | |
| SCHEMBL18520840 | 0.83 | RNASEL (0.59) | RNASELFUT5TGM2 | |
| SCHEMBL20763046 | 0.83 | FUT5 (0.57) | RNASELFUT5P2RY2P2RY4P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |