Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252340 | 0.88 | PIK3CA (0.47) | GAKSMN1; SMN2PDE10ATRPM8USP2 | |
| SCHEMBL21240308 | 0.88 | SMN1; SMN2 (0.47) | GAKSMN1; SMN2PDE10ATRPM8USP2 | |
| SCHEMBL21252225 | 0.79 | NOS1 (0.45) | GAKPDE10ATRPM8MAP4K1MTOR | |
| SCHEMBL20331765 | 0.78 | PDE4B (0.45) | GAKSMN1; SMN2PDE10ATRPM8MAP4K1 | |
| SCHEMBL29578428 | 0.78 | PDE4B (0.45) | GAKSMN1; SMN2PDE10ATRPM8MAP4K1 | |
| SCHEMBL20332257 | 0.77 | SMN1; SMN2 (0.48) | GAKSMN1; SMN2PDE10ATRPM8USP2 | |
| SCHEMBL20331061 | 0.76 | SMN1; SMN2 (0.35) | GAKSMN1; SMN2USP2CYP1A2CYP3A4 | |
| SCHEMBL21252126 | 0.75 | LRRK2 (0.41) | GAKPDE10AMTOR | |
| SCHEMBL21602968 | 0.75 | TRPM8 (0.60) | GAKTRPM8USP2CYP1A2CYP3A4 | |
| SCHEMBL21252344 | 0.75 | PIK3CA (0.47) | GAKSMN1; SMN2PDE10ATRPM8USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |