SCHEMBL2033235

SCHEMBL2033235

COC(=O)C(C#N)=C(C)NC1CC(C)(C)NC(C)(C)C1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MAPK10 P53779 1/20 0.42
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
POLB P06746 2/20 0.40
RECQL P46063 1/20 0.40
EZH2 Q15910 3/20 0.39
USP2 O75604 1/20 0.39
GAA P10253 1/20 0.39
TSHR P16473 1/20 0.38
ALDH1A1 P00352 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7475763 1.00 ATM (0.45) ATML3MBTL1MAPK10MEN1PKM
SCHEMBL19551259 0.78 ATM (0.45) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL11532347 0.77 EZH2 (0.56) ATML3MBTL1MEN1KMT2APOLB
SCHEMBL11528569 0.77 RECQL (0.47) ATML3MBTL1KMT2APOLBRECQL
SCHEMBL11526285 0.75 ATM (0.35) ATML3MBTL1MAPK10MEN1PKM
SCHEMBL8944709 0.75 ATM (0.50) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL11526282 0.71 L3MBTL1 (0.39) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL77511 0.70 RECQL (0.55) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL29453034 0.69 RECQL (0.53) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL3295977 0.69 RECQL (0.57) ATML3MBTL1MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009131958-A2 COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING TRIAZINE DERIVATIVES INSTITUTE FOR ONEWORLD HEALTH (US) 2009-10-29 WO claimed
US-9829606-B2 Method of manufacturing hard coat film, hard coat film, polarizing plate, and liquid crystal display device FUJIFILM CORPORATION (JP) 2017-11-28 US disclosed
US-20150378062-A1 METHOD OF MANUFACTURING HARD COAT FILM, HARD COAT FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2015-12-31 US disclosed
US-9145493-B2 Film, its production method, and polarizer and liquid crystal display device using the film FUJIFILM CORPORATION (JP) 2015-09-29 US disclosed
US-8974214-B2 Device for manufacturing optical film KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2015-03-10 US disclosed
US-20130149405-A1 DEVICE FOR MANUFACTURING OPTICAL FILM KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2013-06-13 US disclosed
US-20130107175-A1 FILM, ITS PRODUCTION METHOD, AND POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE USING THE FILM FUJIFILM CORPORATION (JP) 2013-05-02 US disclosed
US-8236208-B2 Optical cellulose ester film and manufacturing method thereof, and polarizing plate and liquid crystal display device KONICA MINOLTA OPTO, INC. (JP) 2012-08-07 US disclosed
US-7968019-B2 Optical compensation film, method for producing optical compensation film, polarization plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2011-06-28 US disclosed
US-7758777-B2 Polarizing plate protecting film and its manufacturing method, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2010-07-20 US disclosed
US-4426472-A TETRAALKYLPIPERIDINES CIBA-GEIGY CORPORATION (US) 1984-01-17 US disclosed
EP-0002753-B1 STABILISATION OF HEAT-CURABLE METALLIC ENAMEL PAINTS AGAINST THE ACTION OF LIGHT, HUMIDITY AND OXYGEN BY THE ADDITION OF POLYALKYLPIPERIDINE DERIVATIVES CIBA-GEIGY AG (CH) 1983-10-05 EP disclosed
EP-0016723-B1 LIGHT STABILISATION OF TWO-LAYER COMPOSITE LACQUERS CIBA-GEIGY AG (CH) 1983-06-01 EP disclosed
US-4315848-A PROTECTIVE COATING FOR AUTOMOBILES CIBA-GEIGY CORPORATION (US) 1982-02-16 US disclosed
EP-0006564-B1 2-(3.5-DISUBSTITUTED-2-HYDROXYPHENYL)-2H-BENZOTRIAZOLES AND STABILIZED COMPOSITIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1981-12-30 EP disclosed
US-4278589-A 2-[2-Hydroxy-3,5-di-(α,α-dimethylbenzyl)phenyl]-2H-benzotriazole and stabilized compositions CIBA-GEIGY CORPORATION (US) 1981-07-14 US disclosed
US-4278590-A AUTOMOBILE FINISHES CIBA-GEIGY CORPORATION (US) 1981-07-14 US disclosed
EP-0006564-A2 2-(3.5-disubstituted-2-hydroxyphenyl)-2H-benzotriazoles and stabilized compositions containing them CIBA-GEIGY AG (CH) 1980-01-09 EP disclosed
EP-0002753-A2 Stabilisation of heat-curable metallic enamel paints against the action of light, humidity and oxygen by the addition of polyalkylpiperidine derivatives CIBA-GEIGY AG (CH) 1979-07-11 EP disclosed
US-4140673-A REACTING 4-AMINO-PIPERIDINES WITH ENOLIC ETHERS BAYER AKTIENGESELLSCHAFT (DE) 1979-02-20 US disclosed