SCHEMBL7475763

SCHEMBL7475763

COC(=O)/C(C#N)=C(\C)NC1CC(C)(C)NC(C)(C)C1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MAPK10 P53779 1/20 0.42
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
POLB P06746 2/20 0.40
RECQL P46063 1/20 0.40
EZH2 Q15910 3/20 0.39
USP2 O75604 1/20 0.39
GAA P10253 1/20 0.39
TSHR P16473 1/20 0.38
ALDH1A1 P00352 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2033235 1.00 ATM (0.45) ATML3MBTL1MAPK10MEN1PKM
SCHEMBL19551259 0.78 ATM (0.45) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL11532347 0.77 EZH2 (0.56) ATML3MBTL1MEN1KMT2APOLB
SCHEMBL11528569 0.77 RECQL (0.47) ATML3MBTL1KMT2APOLBRECQL
SCHEMBL11526285 0.75 ATM (0.35) ATML3MBTL1MAPK10MEN1PKM
SCHEMBL8944709 0.75 ATM (0.50) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL11526282 0.71 L3MBTL1 (0.39) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL77511 0.70 RECQL (0.55) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL29453034 0.69 RECQL (0.53) ATML3MBTL1MEN1PKMKMT2A
SCHEMBL3295977 0.69 RECQL (0.57) ATML3MBTL1MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0309402-B2 N-substituted hindered amine stabilizers CIBA SC HOLDING AG (CH) 2002-06-12 EP disclosed
EP-0309402-B1 N-substituted hindered amine stabilizers CIBA GEIGY AG (CH) 1995-01-11 EP disclosed
EP-0309402-A1 N-substituted hindered amine stabilizers CIBA-GEIGY AG (CH) 1989-03-29 EP disclosed