Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934104 | 0.83 | SMN1; SMN2 (0.52) | PTPRBPTPN1PTPN2PTPRASMN1; SMN2 | |
| SCHEMBL20347419 | 0.83 | BLM (0.40) | RXRARXRBBLMTPMTAPP | |
| SCHEMBL20350718 | 0.82 | ALDH1A1 (0.50) | RXRARXRBPTPRBSMN1; SMN2HIF1A | |
| SCHEMBL24835573 | 0.80 | PTPRB (0.42) | PTPRBPTPN1PTPN2ALDH1A1CYP3A4 | |
| SCHEMBL20333769 | 0.79 | FFAR1 (0.50) | RXRARXRBLMNA | |
| SCHEMBL19953750 | 0.78 | PTPN1 (0.42) | PTPRBPTPN1PTPN2PTPRA | |
| SCHEMBL20333384 | 0.77 | SMN1; SMN2 (0.50) | PTPN1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL15577125 | 0.76 | BLM (0.40) | BLMPTPRBPTPN1PTPN2PTPRA | |
| SCHEMBL15577140 | 0.76 | BLM (0.40) | BLMPTPRBPTPN1PTPN2PTPRA | |
| SCHEMBL20333717 | 0.76 | THRB (0.53) | SMN1; SMN2ALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119284-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |