Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | PLD2 | O14939 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302481 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL20334017 | 0.88 | HSD11B1 (0.50) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL20302250 | 0.88 | HSD11B1 (0.50) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL29198253 | 0.84 | OPRM1 (0.59) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL29198250 | 0.84 | OPRM1 (0.59) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL319049 | 0.83 | CHRM1 (0.70) | CHRM2CHRM4CHRM1CHRM3SLC18A3 | |
| SCHEMBL20302189 | 0.82 | CHRM2 (0.55) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL20334172 | 0.82 | CHRM2 (0.55) | ALDH1A1MAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL22869746 | 0.81 | KMT2A (0.58) | ALDH1A1MAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL28512418 | 0.81 | KMT2A (0.58) | ALDH1A1MAPK1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118868-A1 | TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2018-06-28 | — | — | WO | disclosed |