Guaiacol

Guaiacol

SCHEMBL2033828

CCOCC.COc1ccccc1O.OCCO

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.67
CA1 P00915 2/20 0.67
CA2 P00918 2/20 0.67
TSHR P16473 2/20 0.67
MAPT P10636 3/20 0.48
LMNA P02545 3/20 0.48
ALDH1A1 P00352 2/20 0.48
CYP3A4 P08684 2/20 0.48
KDM4E B2RXH2 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
MAPK1 P28482 1/20 0.48
HSD17B10 Q99714 1/20 0.48
CA12 O43570 1/20 0.43
CA4 P22748 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
JAK2 O60674 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guaiacol SCHEMBL11198942 0.94 TP53 (0.75) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL27872505 0.90 TSHR (0.82) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL27509885 0.88 CA1 (0.86) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL11570825 0.86 TP53 (0.75) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL4245702 0.86 TSHR (0.58) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL5323161 0.86 TP53 (0.62) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL28330363 0.84 CA1 (0.86) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL27482331 0.83 CA1 (0.69) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL811953 0.82 TP53 (0.82) TP53CA1CA2TSHRMAPT
Guaiacol SCHEMBL29454477 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140045695-A1 Continuous Fiber Layer Comprising an Active Substance on the Basis of Bio-polymers, the Use Thereof, and Method for the Production Thereof BASF SE (DE) 2014-02-13 US disclosed
US-20110136669-A1 Continuous Fiber Layer Comprising an Active Substance on the Basis of Bio-Polymers, the use Thereof, and Method for the Production Thereof BASF SE (DE) 2011-06-09 US disclosed
US-20110129510-A1 FIBROUS SURFACE STRUCTURE CONTAINING ACTIVE INGREDIENTS WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS, USE THEREOF AND METHOD FOR THE PRODUCTION THEREOF BASF SE (DE) 2011-06-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140045695-A1 Continuous Fiber Layer Comprising an Active Substance on the Basis of Bio-polymers, the Use Thereof, and Method for the Production Thereof CUTA, FGB, CD68 TP53 3592/4885CA1 3669/4885CA2 4332/4885
US-20110129510-A1 FIBROUS SURFACE STRUCTURE CONTAINING ACTIVE INGREDIENTS WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS, USE THEREOF AND METHOD FOR THE PRODUCTION THEREOF FIBP, ADAM17, CYP51A1 TP53 4016/4885CA1 1805/4885CA2 2376/4885
US-20110136669-A1 Continuous Fiber Layer Comprising an Active Substance on the Basis of Bio-Polymers, the use Thereof, and Method for the Production Thereof CUTA, FGB, CD68 TP53 3553/4885CA1 3698/4885CA2 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.