Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956955 | 0.82 | RNASEH1 (0.50) | RNASEH1DAOKMT2AHCAR2GAA | |
| Hydrochloric Acid SCHEMBL15956818 | 0.80 | RNASEH1 (0.49) | RNASEH1DAOKMT2AHCAR2GAA | |
| SCHEMBL19037422 | 0.79 | LMNA (0.49) | RNASEH1DAOKMT2AGAATAAR1 | |
| SCHEMBL3210485 | 0.79 | PLA2G10 (0.49) | RNASEH1DAOKMT2AHCAR2GAA | |
| SCHEMBL18419869 | 0.76 | KMT2A (0.43) | RNASEH1DAOKMT2AGAATAAR1 | |
| SCHEMBL18377480 | 0.76 | BRD4 (0.48) | RNASEH1DAOKMT2AGAAALDH1A1 | |
| SCHEMBL15956900 | 0.75 | SMN1; SMN2 (0.52) | RNASEH1KMT2ATSHRALDH1A1 | |
| SCHEMBL25586572 | 0.73 | RNASEH1 (0.37) | RNASEH1DAOKMT2AHCAR2GAA | |
| SCHEMBL25875795 | 0.73 | ALDH1A1 (0.44) | RNASEH1KMT2AALDH1A1 | |
| SCHEMBL21232605 | 0.72 | RNASEH1 (0.43) | RNASEH1DAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |