SCHEMBL20344797

SCHEMBL20344797

C=CCN1C(=O)CCc2cc(N[S+]([O-])Cc3ccc(C)cc3)ccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
RAB9A P51151 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ATAD2 Q6PL18 1/20 0.35
HDAC1 Q13547 4/20 0.34
HDAC8 Q9BY41 4/20 0.34
HDAC6 Q9UBN7 4/20 0.34
CES2 O00748 1/20 0.34
POLB P06746 5/20 0.34
MAPT P10636 5/20 0.34
LMNA P02545 4/20 0.34
CHRNA7 P36544 1/20 0.34
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
THRB P10828 1/20 0.33
MAPK1 P28482 1/20 0.33
RECQL P46063 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20344745 0.88 CES2 (0.35) ALDH1A1ATAD2HDAC1HDAC8HDAC6
SCHEMBL20344798 0.80 BRD4 (0.41) ALDH1A1RAB9ASMN1; SMN2ATAD2HDAC1
SCHEMBL436376 0.78 ATAD2 (0.48) ALDH1A1RAB9ASMN1; SMN2ATAD2POLB
SCHEMBL20344778 0.74 HDAC1 (0.39) ATAD2HDAC1HDAC8HDAC6CES2
SCHEMBL20344756 0.74 HDAC1 (0.37) ATAD2HDAC1HDAC8HDAC6CES2
SCHEMBL20344693 0.73 HDAC6 (0.38) ATAD2HDAC1HDAC8HDAC6CES2
SCHEMBL19805057 0.72 TP53 (0.34) ALDH1A1POLBCHRNA7MEN1KMT2A
SCHEMBL20344775 0.72 GRIN1 (0.37) ATAD2HDAC1HDAC8HDAC6CES2
SCHEMBL12559582 0.70 POLB (0.47) ALDH1A1RAB9ASMN1; SMN2ATAD2POLB
SCHEMBL20344743 0.70 BRD4 (0.38) ATAD2HDAC1HDAC8HDAC6CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3342766-B1 SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES (CN) 2020-12-09 EP disclosed
EP-3342766-A1 SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CN) 2018-07-04 EP disclosed