Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 3/20 | 0.32 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 5/20 | 0.32 |
| ▸ | RBBP4 | Q09028 | 5/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.32 |
| ▸ | AEBP2 | Q6ZN18 | 5/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344808 | 0.91 | GNRHR (0.35) | APPBACE1WDR5FABP4FABP3 | |
| SCHEMBL17039306 | 0.89 | FABP4 (0.35) | FABP4FABP3EEDRBBP4SUZ12 | |
| SCHEMBL17039278 | 0.81 | FABP4 (0.41) | FABP4FABP3GNRHR | |
| SCHEMBL17029056 | 0.81 | NR1I2 (0.42) | FABP4 | |
| SCHEMBL17029028 | 0.81 | NR1I2 (0.42) | FABP4 | |
| SCHEMBL20344817 | 0.80 | NR1I2 (0.36) | FABP4FABP3 | |
| SCHEMBL18364988 | 0.80 | NR1I2 (0.36) | FABP4FABP3 | |
| SCHEMBL17039255 | 0.76 | CLK1 (0.40) | FABP4FABP3RAB9AKDM4ENPC1 | |
| SCHEMBL20344789 | 0.72 | NR1I2 (0.37) | KDM4EMAPTALDH1A1 | |
| SCHEMBL17029048 | 0.72 | NR1I2 (0.44) | FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107913-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2018-07-04 | — | — | EP | disclosed |