Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674059 | 0.88 | ALOX15 (0.48) | MAPTTPMTALOX15TSHRHIF1A | |
| SCHEMBL17858833 | 0.83 | HSP90AA1 (0.47) | MAPTTPMTALOX15TSHRHIF1A | |
| SCHEMBL29177315 | 0.83 | CDK8 (0.49) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL29739565 | 0.83 | CDK8 (0.49) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL1179149 | 0.81 | TPMT (0.56) | MAPTTPMTALOX15TSHRHIF1A | |
| SCHEMBL17943341 | 0.80 | KDM4E (0.49) | MAPTTSHRKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5527447 | 0.79 | TPMT (0.42) | TPMTALOX15TSHRHIF1AKDM4E | |
| SCHEMBL25951737 | 0.79 | ALOX15 (0.41) | MAPTTPMTALOX15TSHRHIF1A | |
| SCHEMBL18362973 | 0.79 | GABRP (0.43) | TPMTALOX15TSHRHIF1AKDM4E | |
| Hydrochloric Acid SCHEMBL1179035 | 0.79 | TPMT (0.54) | MAPTTPMTALOX15TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186741-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186741-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | IMPDH2, IMPDH1, GFPT1 | MAPT 963/4885TPMT 49/4885ALOX15 2953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.