SCHEMBL2035429

SCHEMBL2035429

CSc1ncc(F)c(N=CN(C)C)n1

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.33
RECQL P46063 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
KDM4E B2RXH2 4/20 0.31
MEN1 O00255 2/20 0.31
ALDH1A1 P00352 2/20 0.31
KMT2A Q03164 2/20 0.31
MAPT P10636 2/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16286354 1.00 ALOX15 (0.33) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL12515514 1.00 ALOX15 (0.33) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL31381002 0.81 MEN1 (0.34) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL17012041 0.79 CYP1A2 (0.39) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL13529680 0.78 SMN1; SMN2 (0.40) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL1224326 0.78 ALOX15 (0.34) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL1224399 0.78 ALOX15 (0.34) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL1224327 0.78 ALOX15 (0.34) ALOX15RECQLL3MBTL1KDM4EMEN1
SCHEMBL13530882 0.76 L3MBTL1 (0.31) L3MBTL1
SCHEMBL14730545 0.75 L3MBTL1 (0.35) ALOX15RECQLL3MBTL1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912207-B2 2-aldoximino-5-fluoropyrimidine derivatives Dow AgroSciences, LLP. (US) 2014-12-16 US disclosed
US-20110152300-A1 2-ALDOXIMINO-5-FLUOROPYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152300-A1 2-ALDOXIMINO-5-FLUOROPYRIMIDINE DERIVATIVES AKR7A2, DPYD, DPM1 ALOX15 2023/4885RECQL 1621/4885L3MBTL1 1188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.