Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224327 | 1.00 | ALOX15 (0.34) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL1224326 | 1.00 | ALOX15 (0.34) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL13530892 | 0.84 | — | — | |
| SCHEMBL17012041 | 0.81 | CYP1A2 (0.39) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL14724311 | 0.81 | — | — | |
| SCHEMBL13529680 | 0.80 | SMN1; SMN2 (0.40) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL16286354 | 0.78 | ALOX15 (0.33) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL2035429 | 0.78 | ALOX15 (0.33) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL14730545 | 0.78 | L3MBTL1 (0.35) | ALOX15RECQLALDH1A1KDM4ERAB9A | |
| SCHEMBL13750881 | 0.78 | L3MBTL1 (0.41) | ALOX15RECQLALDH1A1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519512-B1 | N1-ACYL- 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD (IL) | 2019-03-20 | — | — | EP | disclosed |
| US-9862686-B2 | N1-sulfonyl-5-fluoropyrimidinone derivatives | ADAMA MAKHTESHIM LTD. (IL) | 2018-01-09 | — | — | US | disclosed |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-9204653-B2 | 5-fluoro pyrimidine derivatives | DOW AGROSCIENCES LLC (US) | 2015-12-08 | — | — | US | disclosed |
| US-9204653-B2 | 5-fluoro pyrimidine derivatives | DOW AGROSCIENCES LLC (US) | 2015-12-08 | — | — | US | disclosed |
| US-9174970-B2 | 5-fluoro pyrimidine derivatives | DOW AGROSCIENCES LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174970-B2 | 5-fluoro pyrimidine derivatives | DOW AGROSCIENCES LLC (US) | 2015-11-03 | — | — | US | disclosed |
| EP-2461686-B1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2011017547-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20110034493-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034493-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| WO-2011017540-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20100022538-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2010-01-28 | — | — | US | disclosed |
| US-20100022538-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2010-01-28 | — | — | US | disclosed |
| US-20090203647-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203647-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2009094442-A2 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022538-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DPYD, DPM1, DDX5 | ALOX15 4046/4885RECQL 726/4885ALDH1A1 1302/4885 |
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DDT, CASP2, GDI1 | ALOX15 4542/4885RECQL 2597/4885ALDH1A1 415/4885 |
| US-20090203647-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DPYD, DPM1, DDX5 | ALOX15 4046/4885RECQL 726/4885ALDH1A1 1302/4885 |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | ALOX15 4014/4885RECQL 1819/4885ALDH1A1 528/4885 |
| US-20110034493-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, SULT1E1, CYP1A1 | ALOX15 4400/4885RECQL 2083/4885ALDH1A1 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.