Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20354516 | 0.86 | DRD2 (0.47) | RIPK1CREBBPPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24258522 | 0.84 | CREBBP (0.65) | RIPK1CREBBPPIK3CAPIK3CBPIK3CG | |
| SCHEMBL676648 | 0.82 | MAPT (0.42) | RIPK1CREBBPALDH1A1GAAMAPT | |
| SCHEMBL1950203 | 0.81 | KDM4E (0.42) | ALDH1A1GAAMAPTHTTDRD2 | |
| SCHEMBL14863559 | 0.81 | HTT (0.43) | RIPK1PIK3CAPIK3CBPIK3CGMAPT | |
| Hydrochloric Acid SCHEMBL7481044 | 0.80 | KDM4E (0.45) | GAAMAPTHTTDRD2DRD1 | |
| SCHEMBL18255843 | 0.78 | PIK3CA (0.43) | RIPK1PIK3CAPIK3CBPIK3CGHTT | |
| SCHEMBL5022145 | 0.77 | KMT2A (0.52) | CREBBPPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL29388834 | 0.77 | MAOA (0.53) | HTTDRD2DRD1DRD4DRD5 | |
| SCHEMBL10455557 | 0.77 | MAOA (0.53) | HTTDRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| EP-3564232-A1 | BMP-SIGNAL-INHIBITING COMPOUND | Riken (JP) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018124001-A1 | BMP-SIGNAL-INHIBITING COMPOUND | 国立研究開発法人理化学研究所 | 2018-07-05 | — | — | WO | disclosed |