Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20354517 | 0.84 | RIPK1 (0.51) | CREBBPRIPK1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL19657514 | 0.79 | CREBBP (1.00) | CREBBP | |
| SCHEMBL20354516 | 0.75 | DRD2 (0.47) | CREBBPRIPK1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1950203 | 0.71 | KDM4E (0.42) | — | |
| SCHEMBL14863559 | 0.71 | HTT (0.43) | RIPK1PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL23251650 | 0.70 | PIK3CA (0.58) | CREBBPPIK3CA | |
| Hydrochloric Acid SCHEMBL7481044 | 0.70 | KDM4E (0.45) | — | |
| SCHEMBL14003406 | 0.69 | KDM4E (0.54) | CREBBPAPPBACE1 | |
| SCHEMBL676648 | 0.69 | MAPT (0.42) | CREBBPRIPK1 | |
| SCHEMBL18255843 | 0.68 | PIK3CA (0.43) | RIPK1PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |