Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 1.00 |
| ▸ | DRD2 | P14416 | 10/20 | 1.00 |
| ▸ | HTR7 | P34969 | 10/20 | 1.00 |
| ▸ | DRD3 | P35462 | 10/20 | 1.00 |
| ▸ | HTR2B | P41595 | 10/20 | 1.00 |
| ▸ | HTR2A | P28223 | 9/20 | 1.00 |
| ▸ | HRH1 | P35367 | 8/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HTR5A | P47898 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31093171 | 0.91 | HTR1A (0.84) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL20364974 | 0.91 | DRD2 (1.00) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL20358377 | 0.89 | HTR1A (1.00) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL7647706 | 0.89 | HTR1A (0.81) | HTR1ADRD2HTR7DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL20359591 | 0.89 | DRD2 (0.97) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL20364978 | 0.89 | DRD2 (1.00) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL7647981 | 0.89 | HTR1A (1.00) | HTR1ADRD2HTR7DRD3HTR2B | |
| SCHEMBL20364967 | 0.88 | HTR1A (0.79) | HTR1ADRD2HTR7DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL20359225 | 0.88 | DRD2 (0.97) | HTR1ADRD2HTR7DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL20358549 | 0.88 | HTR1A (0.79) | HTR1ADRD2HTR7DRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180193330-A1 | ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS | FLORIDA A&M UNIVERSITY | 2018-07-12 | — | — | US | disclosed |
| US-20180193330-A1 | ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS | FLORIDA A&M UNIVERSITY | 2018-07-12 | — | — | US | disclosed |
| US-20180193330-A1 | ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS | FLORIDA A&M UNIVERSITY | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180193330-A1 | ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS | NTSR2, HTR3B, NTSR1 | HTR1A 28/4885DRD2 226/4885HTR7 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.