Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.32 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29896270 | 1.00 | NOS1 (0.37) | NOS1AXLIDO1METAP2TRPA1 | |
| SCHEMBL29896274 | 1.00 | NOS1 (0.37) | NOS1AXLIDO1METAP2TRPA1 | |
| SCHEMBL12321248 | 0.70 | NOS1 (0.56) | NOS1AXLIDO1METAP2TRPA1 | |
| SCHEMBL20002212 | 0.67 | CDK2 (0.47) | NOS1AXLCDK2CCNA1FLT3 | |
| SCHEMBL19118540 | 0.63 | IDO1 (0.40) | NOS1AXLIDO1METAP2CDK2 | |
| SCHEMBL19100578 | 0.63 | — | — | |
| SCHEMBL14052699 | 0.63 | ALDH1A1 (0.42) | MEN1ALDH1A1LMNAMAPTTSHR | |
| SCHEMBL3201541 | 0.62 | TRPV1 (0.34) | NOS1AXLIDO1CDK2CCNA1 | |
| SCHEMBL29424626 | 0.61 | MAOA (0.43) | ESR2KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL25757634 | 0.61 | MET (0.37) | NOS1AXLIDO1CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011077502-A1 | DIHYDROTHIENO[2,3-E]INDAZOLE COMPOUND | 杏林製薬株式会社 (JP) | 2011-06-30 | — | — | WO | disclosed |
| JP-2010006717-A | DIHYDROTHIENO[2,3-e]INDAZOLE COMPOUND | KYORIN PHARMACEUT CO LTD | 2010-01-14 | — | — | JP | disclosed |