Urea

Urea

SCHEMBL20359695

NC(N)=O.OB(O)O.OB(O)O.OB(O)O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.67
TDP1 Q9NUW8 4/20 0.67
ALDH1A1 P00352 4/20 0.67
OR51E2 Q9H255 1/20 0.67
ACHE P22303 1/20 0.46
TSHR P16473 4/20 0.44
BLM P54132 4/20 0.42
PMP22 Q01453 3/20 0.42
ALOX15 P16050 2/20 0.42
LDHA P00338 2/20 0.39
LDHB P07195 1/20 0.39
CYP3A4 P08684 3/20 0.36
NFKB1 P19838 2/20 0.36
HPGD P15428 2/20 0.36
HSD17B10 Q99714 2/20 0.36
CYP1A2 P05177 2/20 0.36
THPO P40225 2/20 0.36
EHMT2 Q96KQ7 1/20 0.36
EHMT1 Q9H9B1 1/20 0.36
MAOA P21397 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL780636 1.00
Urea SCHEMBL5577087 0.87 LMNA (0.50) LMNATDP1ALDH1A1OR51E2ACHE
Carbamic Acid SCHEMBL2552894 0.84
SCHEMBL3921562 0.84
Urea SCHEMBL8560069 0.82 LMNA (1.00) LMNATDP1ALDH1A1OR51E2ACHE
Urea SCHEMBL411583 0.82
Urea SCHEMBL187990 0.82
Urea SCHEMBL7756359 0.82 LMNA (1.00) LMNATDP1ALDH1A1OR51E2ACHE
Urea SCHEMBL8434002 0.82 LMNA (1.00) LMNATDP1ALDH1A1OR51E2ACHE
Urea SCHEMBL20641124 0.82 LMNA (1.00) LMNATDP1ALDH1A1OR51E2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114577886-B Reagent, kit and detection method for detecting exogenous harmful substances in traditional Chinese medicine 天津中医药大学 2023-07-25 CN claimed
CN-114577886-A Reagent, kit and detection method for detecting exogenous harmful substances in traditional Chinese medicine 天津中医药大学 2022-06-03 CN claimed
CN-114577886-B Reagent, kit and detection method for detecting exogenous harmful substances in traditional Chinese medicine 天津中医药大学 2023-07-25 CN disclosed
CN-116042675-A Method for high-efficiency recombinant expression and protein purification of ADP-ribosyl cyclase 上海观龄基因科技有限公司 2023-05-02 CN disclosed
US-20230022745-A1 Methods for Labeling a Population of RNA Molecules NEW ENGLAND BIOLABS, INC. (US) 2023-01-26 US disclosed
CN-114577886-A Reagent, kit and detection method for detecting exogenous harmful substances in traditional Chinese medicine 天津中医药大学 2022-06-03 CN disclosed
US-20180195061-A1 Methods for Labeling a Population of RNA Molecules NEW ENGLAND BIOLABS, INC. (US) 2018-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180195061-A1 Methods for Labeling a Population of RNA Molecules RNGTT, RNMT, MTAP LMNA 2087/4885TDP1 455/4885ALDH1A1 2357/4885
US-20230022745-A1 Methods for Labeling a Population of RNA Molecules RNGTT, RNMT, MTAP LMNA 2087/4885TDP1 455/4885ALDH1A1 2357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.