Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18365809 | 0.78 | POLB (0.41) | PIK3CAKDM4ELMNAALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL21818893 | 0.77 | POLB (0.41) | PIK3CAKDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL14962437 | 0.76 | MGLL (0.41) | IDO1LMNAALDH1A1 | |
| SCHEMBL17454164 | 0.75 | DPP4 (0.41) | PIK3CAL3MBTL1KDM4ELMNAALDH1A1 | |
| SCHEMBL17579506 | 0.75 | MAPT (0.39) | L3MBTL1IDO1KDM4EALDH1A1RAB9A | |
| SCHEMBL30236815 | 0.75 | DRD3 (0.43) | IDO1KDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL23144554 | 0.74 | ALDH1A1 (0.49) | IDO1LMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17591384 | 0.72 | KCNK3 (0.47) | ALDH1A1 | |
| SCHEMBL31714780 | 0.72 | POLB (0.44) | PIK3CAL3MBTL1KDM4ELMNAALDH1A1 | |
| SCHEMBL24692798 | 0.71 | IDO1 (0.35) | IDO1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | ELI LILLY AND COMPANY (US) | 2019-02-05 | — | — | US | disclosed |
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | ELI LILLY AND COMPANY (US) | 2019-02-05 | — | — | US | disclosed |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | ELI LILLY AND COMPANY | 2018-07-12 | — | — | US | disclosed |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | ELI LILLY AND COMPANY | 2018-07-12 | — | — | US | disclosed |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | ELI LILLY AND COMPANY | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | INSR, GPR119, GLP1R | PIK3CA 2770/4885L3MBTL1 2591/4885IDO1 2719/4885 |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | INSR, GPR119, GLP1R | PIK3CA 2893/4885L3MBTL1 3076/4885IDO1 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.