Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12622116 | 0.82 | ALDH1A1 (0.57) | HTTKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12622121 | 0.75 | HTT (0.53) | HTTKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12655508 | 0.72 | HTT (0.62) | HTTKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12625901 | 0.72 | POLB (0.56) | HTTKDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL12623924 | 0.71 | HTT (0.49) | HTTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12622016 | 0.71 | MAPK1 (0.46) | HTTKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12621830 | 0.69 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL13353201 | 0.69 | LMNA (0.60) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL12626275 | 0.68 | GPR119 (0.49) | HTTKDM4ESMN1; SMN2NPC1LMNA | |
| SCHEMBL12624085 | 0.67 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872899-B1 | ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT | PAIN THERAPEUTICS INC (US) | 2018-07-11 | — | — | EP | disclosed |