Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.62 |
| ▸ | CHRNA5 | P30532 | 3/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037831 | 0.81 | CHRNB2 (0.64) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2040546 | 0.81 | RAB9A (0.43) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2036408 | 0.80 | NPC1 (0.41) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2037579 | 0.78 | RAB9A (0.42) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2041296 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL4698877 | 0.72 | GRM5 (0.74) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL3752704 | 0.72 | CHRNB2 (0.73) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2036415 | 0.70 | CHRNB2 (0.74) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL4698820 | 0.70 | CHRNB2 (0.61) | CHRNB2CHRNA5CHRNA4NPC1RAB9A | |
| SCHEMBL2040967 | 0.70 | CHRNB2 (0.61) | CHRNB2CHRNA5CHRNA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073298-A1 | TETRAZOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073298-A1 | TETRAZOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-06-23 | — | — | WO | disclosed |