Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 17/20 | 0.43 |
| ▸ | NPC1 | O15118 | 16/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037579 | 0.84 | RAB9A (0.42) | RAB9ANPC1MAPTPKMKDM4E | |
| SCHEMBL2036940 | 0.81 | CHRNB2 (0.62) | RAB9ANPC1MAPTPKMCHRNB2 | |
| SCHEMBL2037498 | 0.80 | RAB9A (0.43) | RAB9ANPC1MAPTPKMKDM4E | |
| SCHEMBL2039061 | 0.74 | CHRNB2 (0.74) | RAB9ANPC1MAPTKDM4ENFKB1 | |
| SCHEMBL2036408 | 0.72 | NPC1 (0.41) | RAB9ANPC1PKMCHRNB2CHRNA5 | |
| SCHEMBL2036415 | 0.69 | CHRNB2 (0.74) | RAB9ANPC1MAPTPKMNFKB1 | |
| SCHEMBL4699663 | 0.65 | GRM5 (0.63) | — | |
| SCHEMBL17571425 | 0.65 | ELANE (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL29880570 | 0.65 | ELANE (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL2037353 | 0.63 | RAB9A (0.43) | RAB9ANPC1MAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073298-A1 | TETRAZOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073298-A1 | TETRAZOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-06-23 | — | — | WO | disclosed |