Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18635470 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL7813031 | 0.80 | ALOX5 (0.45) | ALOX5NR1H2 | |
| SCHEMBL8611773 | 0.80 | SMN1; SMN2 (0.48) | ALOX5SMN1; SMN2L3MBTL1NR1H2MEN1 | |
| SCHEMBL9905371 | 0.79 | SMN1; SMN2 (0.42) | ALOX5SMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL7803741 | 0.79 | ALOX5 (0.44) | ALOX5NR1H2 | |
| SCHEMBL16230722 | 0.77 | NR1H2 (0.47) | ALOX5SMN1; SMN2L3MBTL1NR1H2MEN1 | |
| SCHEMBL20148783 | 0.76 | ALOX5 (0.46) | ALOX5SMN1; SMN2L3MBTL1NR1H2MEN1 | |
| SCHEMBL7816672 | 0.73 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL7813254 | 0.72 | ALOX5 (0.60) | ALOX5MEN1KMT2A | |
| SCHEMBL5568072 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |