Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 16/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813031 | 0.83 | ALOX5 (0.45) | ALOX5NR1H2MAP3K14 | |
| SCHEMBL7816672 | 0.82 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL7803912 | 0.81 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL2037282 | 0.79 | ALOX5 (0.48) | ALOX5NR1H2 | |
| SCHEMBL7810732 | 0.74 | ALOX5 (0.64) | ALOX5 | |
| SCHEMBL7803702 | 0.73 | CCR1 (0.38) | — | |
| SCHEMBL9597752 | 0.72 | ALOX5 (0.62) | ALOX5 | |
| SCHEMBL24914919 | 0.70 | CCR1 (0.35) | — | |
| SCHEMBL7813254 | 0.70 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL20436477 | 0.69 | CCR1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788497-B1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 2001-05-23 | — | — | EP | disclosed |
| US-5552437-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |
| WO-1996013500-A1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |