Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN7A | Q01118 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18326368 | 0.87 | HTT (0.48) | KCNH2KDM4EGLA | |
| SCHEMBL20373742 | 0.74 | MAPK1 (0.43) | SCN7ASCN5ASCN2ASCN8AKCNH2 | |
| SCHEMBL30665881 | 0.73 | BRPF1 (0.52) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL17576626 | 0.73 | BRPF1 (0.52) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL18326383 | 0.71 | PDE5A (0.46) | HTR2AKDM4EALDH1A1 | |
| SCHEMBL18326364 | 0.71 | ACHE (0.47) | HTR6HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL18326370 | 0.71 | PDE5A (0.41) | HTR2AHTR2CKDM4EALDH1A1GLA | |
| SCHEMBL16905795 | 0.68 | CREBBP (0.51) | — | |
| SCHEMBL20373438 | 0.68 | LMNA (0.41) | SCN7ASCN5ASCN2ASCN8AKDM4E | |
| SCHEMBL16896825 | 0.68 | HTR2A (0.44) | HTR2AHTR2CKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |